Novel Substituted Benzothiazole Compounds for Treating Huntington’s Disease

Potential Vaccines for Treating Crohn\'s Disease

Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, developm...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

2-Substituted Hydrazino-6-Fluoro-1,3-Benzothiazole: Synthesis and Characterization of new Novel AntimicrobiaL Agents

A series of novel 2-substituted hydrazino-6-fluoro-1,3-benzothiazole derivatives were synthesized by synthesizing the 2-hydrazino-6-fluorobenzothiazole and refluxing of this with different substituted acetophenones. The synthesized compounds were evaluated for their possible antimicrobial activity. The structures of few representative compounds were elucidated by IR and NMR. For present work ef...

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.

Alzheimer's disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a...

Synthesis, Characterization and Biological Activity of Various Substituted Benzothiazole Derivatives

A series of 2-(benzo[d]thiazol-2-ylthio)-N-(2-oxoindolin-3-ylidene)acetohydrazide (3a3g), 2-(benzo [d]thiazol-2-ylthio)-N-(2,4’-dioxospiro[indolin-3,2’-thiazolidin)-3’yl)acetamide (4a-4g) and 2'-((benzo[d]thiazol-2-ylthio)methyl)spiro[indoline-3,5'thiazolo[4,3-b][1,3,4]oxadiazol]-2-ones (5a-5g) have been synthesized and screened for their anti-inflammatory, analgesic and antibacterial activitie...